Description

Brand Names:

• Fioricet
• Esgic
• Orbivan
• Dolgic Plus (may vary by region)
• Components and Functions:
• Acetaminophen (Paracetamol)
• Function: Pain reliever (analgesic) and fever reducer (antipyretic)
• Mechanism: Works by inhibiting prostaglandin synthesis in the central nervous system.

Butalbital

• Function: Barbiturate sedative
• Mechanism: Depresses the central nervous system to produce a calming effect, which can reduce anxiety and muscle tension associated with headaches.
• Caffeine
• Function: Central nervous system stimulant
• Mechanism: Constricts dilated blood vessels in the brain, which are believed to contribute to headache pain; also enhances the effects of acetaminophen.
• Typical Dosage (for Adults):
• Acetaminophen: 325–650 mg
• Butalbital: 50 mg
• Caffeine: 40 mg
• Taken every 4 hours as needed. Do not exceed 6 tablets or capsules per day.
• Dosage may vary depending on formulation and patient-specific factors. Always follow prescribing instructions.

Uses:

• Tension headaches
• Migraine headaches (off-label in some cases)
• Muscle contraction headaches
• Common Side Effects:
• Drowsiness
• Dizziness
• Lightheadedness
• Nausea
• Abdominal pain
• Serious Side Effects (Seek medical attention):
• Shortness of breath
• Liver damage (especially with acetaminophen overdose)
• Allergic reactions (rash, itching, swelling)
• Mood or behavior changes
• Signs of barbiturate dependence or withdrawal

Warnings and Precautions:

• Liver Toxicity: High doses of acetaminophen can cause severe liver damage. Avoid alcohol while taking this medication.
• Addiction/Dependence: Butalbital is habit-forming. Risk increases with prolonged use or high doses.
• Drug Interactions: May interact with sedatives, alcohol, antidepressants, and other CNS depressants.
• Pregnancy/Breastfeeding: Use only if clearly needed; butalbital can harm the fetus or newborn.
• Driving and Operating Machinery: Can impair alertness and coordination.
• Contraindications:
• Allergy to any of the components
• Porphyria (a rare blood disorder)
• Severe liver disease
• History of substance abuse (use with extreme caution)
• Overdose Symptoms:
• Acetaminophen: Nausea, vomiting, loss of appetite, sweating, confusion, jaundice (yellowing skin/eyes)
• Butalbital: Slow or shallow breathing, unconsciousness, coma
• Caffeine: Restlessness, rapid heartbeat, muscle tremors

Storage:

• Store at room temperature away from moisture and light.
• Keep out of reach of children and pets.

Important Notes:

• Do not use for more than a few days unless directed by a doctor.
• Chronic use can lead to medication-overuse headaches (rebound headaches).
• Always consult a healthcare provider before combining with other medications or supplements